Prescription skincare treatments can be highly effective, but they often come with potential side effects. These vary depending on the specific medication, your skin type, and how your body responds. Here’s a general overview of common side effects by category:
Topical Prescription Treatments
These include retinoids, antibiotics, corticosteroids, and other medicated creams or gels.
Common side effects:
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Dryness and peeling (especially with retinoids like tretinoin)
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Redness and irritation
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Burning or stinging
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Increased sun sensitivity (photosensitivity)
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Skin thinning (from long-term steroid use)
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Allergic reactions (rash, itching, swelling)
Oral Prescription Treatments
These include antibiotics, hormonal treatments, isotretinoin (Accutane), and others.
Common side effects:
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Antibiotics (like doxycycline or minocycline):
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Nausea or stomach upset
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Yeast infections
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Increased sun sensitivity
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Antibiotic resistance with long-term use
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Hormonal treatments (like birth control pills or spironolactone):
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Breast tenderness
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Irregular periods
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Headaches
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Mood changes
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Potassium imbalance (spironolactone)
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Isotretinoin (Accutane):
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Extremely dry skin and lips
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Nosebleeds
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Joint and muscle pain
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Mood changes
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Birth defects (if taken during pregnancy)
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Liver issues or high cholesterol
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Injectables and Other Dermatologic Procedures
Such as corticosteroid injections or botulinum toxin.
Possible side effects:
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Pain at the injection site
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Swelling or bruising
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Skin atrophy (with steroids)
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Temporary asymmetry (with Botox or fillers)
What to Do
If you’re on a prescription and experience side effects:
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Don’t stop suddenly unless advised by your doctor.
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Moisturize and use gentle skincare to support your skin barrier.
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Talk to your dermatologist — they may adjust your dosage or switch your treatment.